赵莉
发布时间:2024-02-27   访问次数:632







赵莉



生物工程专业:硕士生导师

生物与医药专业(生物工程领域):硕士生导师





个人简介:

赵莉,女;工学博士,讲师。2008年博士毕业于3044am永利集团官网,并留校工作。2018-2019获国家留学基金委资助,赴美国佐治亚理工学院(Georgia Institute of Technology)访学一年。


主要研究方向:

1.  功能微生物及天然活性物质的筛选及应用;

2.  有机酸、氨基酸、多元醇等平台化合物的绿色生物制造;

3.  重组酶蛋白、药物蛋白的发酵代谢调控


主持或主要参与项目:

1.双菌两步法产3-羟基丙酸机制解析及高效体系构建(NO.21506017),国家自然科学基金,主持

2.1,3-丙二醇氧化还原酶强化对克雷伯杆菌生长代谢的影响机制(NO.13ZR1412100),上海市自然科学基金,主持

3.乳酸菌发酵食用酵素产品开发,上海清美绿色食品(集团)有限公司,主持

4.具有情绪调节作用精油分子的虚拟高通量筛选,资生堂(中国)投资有限公司,主持

5.护肤生物活性肽开发研究,上海皓以科技有限公司,主持

6.几种工业用酶酶库的构建及酶的功能研究,生物反应器国家重点实验室特别资助项目主持

7.药品与食品工业酶高效制备与催化技术(2021YFC2100300),创新国家重点研发子课题,参与

8.新型农药精草铵膦绿色制造技术及应用,企业横向,参与

9.微生物甾醇侧链降解过程中母核降解机制研究与改进(NO.3157011389)国家自然科学基金,参与

10.分岐杆菌植物甾醇侧链降解与辅因子循环相关性研究(NO.21276083),国家自然科学基金,参与

11.生物技术药物中试放大及分离纯化技术平台(NO.2012ZX09304009),重大新药创制项目,参与

12.柠檬酸、葡萄糖酸的生物转化技术(NO.20111102A213)863计划课题重大化工产品的先进生物制造,参与


教学工作:

《食品微生物学实验》,本科专业必修课程,48学时,1.5学分

《食品原料安全控制》,本科专业必修课程,16学时,1学分

《食品营养与健康》,本科公共选修课程,32学时,2学分


代表性论文(*通讯作者):

1.  Deyi Yin #, Li Zhao#, Sijing Deng, Yaqi Xie, Kum-Song Ro, Zeyong Yang, Lei Du*, Jingli Xie*, Dongzhi Wei, Lactiplantibacillus plantarum X7022 Plays Roles on Aging Mice with Memory Impairment Induced by D-Galactose Through Restoring Neuronal Damage, Relieving Inflammation and Oxidative Stress, Probiotics Antimicrob Proteins, 2024 Jan 6. doi: 10.1007/s12602-023-10208-w.

2.  Kum-Song Ro#, Li Zhao#, Yangting Hu, Minli Ge, Lei Du*, Jingli Xie*, Anti-hyperuricemic properties and mechanism of Lactiplantibacillus plantarum X7023, Process Biochemistry, 2024,36: 26-37.

3.  Xiaoying Xie#, Kum-Song Ro#, Huiling Wu, Lei Du, Li Zhao*, Jingli Xie*, Dongzhi Wei, A novel γ-aminobutyric acid biosynthetic pathway in Lentilactobacillus curieaeCCTCC M 2011381TProcess Biochemistry2023124:160-167.

4.  Li Zhao, Jiawei Zhu, Kum-Song Ro, Jingli Xie*, Dongzhi Wei*Discovery of a novel acrylic acid formation pathway in Gluconobacter oxydans and its application in biosynthesis of acrylic acid from glycerolProcess Biochemistry, 2022,18:182-189.

5.  Kum-Song Ro, Ying Chen, Lei Du, Lixin Wang, Li Zhao*, Jingli Xie*, Dongzhi WeiImprovement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentationProcess Biochemistry, 2022,115: 110-117.

6.  Guang Liu, Yafan Liu, Kum-Song Ro, Lei Du, Ya-Jie TangLi Zhao*, Jingli Xie, Dongzhi Wei Genomic characteristics of a novel strain Lactiplantibacillus plantarum X7021 isolated from the brine of stinky tofu for the application in food fermentationLWT-Food Science and Technology,2022,156:113054

7.  Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao*, Meidong LangNovel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressingJournal of Materials Science & Technology, 2021,89:225-232.

8.  Jiawei Zhu, Jingli Xie, Liujing Wei, Jinping Lin, Li Zhao*, Dongzhi Wei*Identification of the enzymes responsible for 3-hydroxypropionic acid formation and their use in improving 3-hydroxypropionic acid production in Gluconobacter oxydans DSM 2003, Bioresource Technology, 2018,265:328-333.

9.  Yunlong Sun, Changlin Chen, Heng Xu, Kun Lei, Guanzhe Xu, Li Zhao*, Meidong Lang*, Surface modification of silicon wafer by grafting zwitterionic polymers to improve its antifouling property,Applied Surface Science, 2017,419: 642-649.

10.  Yunlong Sun, Changlin Chen,·Heng Xu,·Guanzhe Xu, Li Zhao*, Meidong   Lang*, Synthesis and antibacterial performance of functional organic-inorganic silica nanocomposites based on novel zwitterionic polymer, Journal of Inorganic and Organometallic Polymers and Materials,2017,27(5):1351-1364.

11.  Li Zhao, Jinping Lin, Hualei Wang, Jingli Xie, Dongzhi Wei*, Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans,Bioprocess and Biosystems Engineering,2015, 38(12):2487-2495.

12.  Zhao Li, Zheng Yu, Ma Xingyuan*, Wei Dongzhi*, Effects of over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions, Bioprocess and Biosystems Engineering, 2009,32(3):313-320.

13.  Zhao Li, Ma Xingyuan, Zheng Yu, Zhang Jianguo, Wei Guodong, Wei Dongzhi*, Over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase in Klebsiella pneumoniae and their effects on conversion of glycerol into 1,3-propanediol in resting cell system, Journal of Chemical Technology and Biotechnology, 2009,84(4):626-632.


参编教材:

食品微生物检验学》中国轻工业出版社2019.2,中国轻工业“十三五”规划教材

《现代食品微生物学》科学出版社2021.11,科学出版社“十三五”高等教育研究生规划教材


联系方式:

上海市徐汇区梅陇路130号,邮编:200237

办公室:实验十八楼707

手机号:13817206675

办公电话:021-64251803

微信:1387206675

邮箱:zhaoli@ecust.edu.cn